Bone metastases result in considerable morbidity and complex demands on health care resources, affecting quality of life and independence over years rather than months.
The considerable relief energy and complex topography of the gullies in a natural, vegetated landscape were found to be a challenge to digital photogrammetric techniques, introducing errors which inhibit fully automated DEM generation.
Considerable amounts of toxic and complex dyes are discharged directly into the Noyyal River as effluent and also into wastewater treatment plants by industrial units, thus imposing a selective pressure on the microbial flora residing in wastewater habitats.
It includes splendid pieces by the likes of Steinem, Katha Pollitt, Jessica Valenti, Amy Alexander, Linda Hirshman, Amanda Fortini, Rebecca Traister, Michelle Goldberg, Emily Bazelon and Dahlia Lithwick--all of whom shed considerable light on the varied and complex nuances of gender and feminist constructions raised by the Palin phenomenon.
Although there is considerable evidence for a strong and complex interplay between the metabolic system and the (development of) the HPA-axis [80], [98], the exact mechanisms can not be derived from the current data-set and await future studies.
Moreover, we focused on two most basic types of alternative splicing events, thus excluding a considerable fraction of intron retentions and complex splicing events.
All three are difficult and complex, and present considerable challenges.
It wasn't a simple change, as recreating the signature performance and durability characteristics required a "new and complex chemistry with considerable iteration until we got it just right," said Michael Mahoney, Titleist's VP of Golf Ball Marketing.
Overall, STAT1/3 DNA-binding complexes are predominantly present in the vast majority of samples (20 out of 22); however, activity status and complex composition show considerable variability.
