"considerable alterations" is a correct and usable phrase in written English.
It describes a significant or large change made to something. It is commonly used in formal or technical writing, but can also be used in everyday language. Example: The design of the building underwent considerable alterations before it was approved for construction.
The heterogeneity of alveolar microstructure that is accounted for in image-based models resulted in considerable alterations to the shape of the 129Xe diffusive uptake curve when compared to 1D models.
The Borana rangelands have undergone considerable alterations between 1987 and 2003.
Strong increase of hole mobility and decrease of hole concentration have been observed in CrSi2 epitaxial films on Si(111) [3] that corresponds to considerable alterations in their band structure.
However, we did not find any considerable alterations in HAT activity with SFN treatment in these breast cells (Fig 5C).
Given the functions of miRNAs in post-transcriptional gene silencing, loss of Dicer and all microRNAs would be expected to result in considerable alterations in mRNA levels and associated phenotypic changes.
Considerable alterations in the DNA binding activity of SRF upon serum induction are either not observed or are associated with additional events such as phosphorylation, depending on the cell type, the stimulus and the target gene [22], [23], [24], [25].
The electrode could be used for at least one month without a considerable alteration in its potential.
Holy Trinity Church, after undergoing considerable alteration in 1799, was well restored in the early 1900s and is one of the most impressive churches in Scotland.
Hot exoplanets with semi-major axes smaller than 0.05 AU can go considerable alteration from the high energy radiation of their host stars radiation from driving winds to altering the thermal profiles to disintegrating nearby planets.
Opencast coal mining activities trigger considerable alteration of soil structure, and characterizing the spatial variability of soil particle size distribution (PSD) quantitatively can contribute to understand mined soil properties and perform mined land rehabilitation.
Surprisingly, addition of organoclay to the blends promoted a drastic increase in the notched Izod impact strength and a considerable alteration of the shape of the dispersed EVA phase when the organoclay is located in this phase.
