Globally, footballers' risk of concussion is considered to be substantial, accounting for a quarter of all injuries amongst elite male players [24, 25].
Atoms, fundamental kinds of stuff, gods, or abstract entities, such as Platonic Forms or numbers, might be considered to be substantial to the point of being indestructible or eternal: they last at least as long as the world exists and, in the case of gods or God, or abstract entities, perhaps longer.
Values larger than 0.60 were considered to be substantial [ 38] and items were discarded if the estimated ICCs or kappa values were below 0.60 [ 39].
Given that dry eye is highly prevalent among people of working age as well as in the elderly, its impact on work productivity is considered to be substantial.
If the P-value was less than 0.10 and I exceeded 50% and visual inspection of forest plots was indicative, heterogeneity was considered to be substantial and reasons for it were sought by doing a sensitivity analysis.
Oxidative stress is considered to be substantial, if not crucial, in the initiation and development of many current conditions and diseases, including: inflammation, autoimmune diseases, cataract, cancer, Parkinson's disease, arteriosclerosis and aging [ 2, 10].
One further caveat of using DNA extracted from WBC is the relative contributions made by the respective cell types [ 57], although the overall impact of blood cell composition across individuals is not considered to be substantial [ 55].
