Considering the prioritization of mutation operators, based on DCL R (o k ), presented in Table 5 (p. 16), we applied the mutation operators incrementally.
The field of mixtures research has evolved from evaluating simple combinations of chemicals in search of interactions to considering the prioritization of mixtures for study based on exposure and systems biology.
Another extension is to consider the "edge prioritization" that suggested in early literatures [ 12, 52].
Although several researchers consider that the prioritization stage in HTA is value-laden and that a greater involvement of stakeholders (including patients) would be important [ 10, 25], patients are mostly excluded from this stage in HTA [ 10], with some exceptions.
Policy makers should consider the possibility of explicit prioritization at the outset.
Users with G Factor ≤−3 dB are assumed to have insufficient radio channel quality, and therefore, they are not considered in the prioritization algorithm (see Section 5.3).
Although it is possible to calculate P-values of the interacting pairs and use them as cutoffs for prioritization, we consider the use of P-value cutoffs inappropriate.
With this knowledge, user demands are considered in the prioritization of technical requirements.
Bearers with insufficient radio channel quality are not considered in the prioritization algorithm and are assumed to set (F_{k}^{text {QCI}_{m}}=1).
Finally, different perspectives could be elaborated upon and considered during the prioritization of interventions, since the discussion group consists of a variety of different stakeholders including members of research councils, research managers, researchers and research users.
