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Even though the exact underlying mechanisms of such varied cellular responses are still unknown, we can consider the alteration of four possibilities: (1) cisplatin uptake, (2) intracellular signaling, (3) intracellular efflux of cisplatin, and (4) inactivation of cisplatin.
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To illustrate how a change in parameters that define critical associations in the underlying population influences the observed effect and to guide the reader on how to use the material in the Supplementary Appendix, let us consider the alterations that occur if we change the association between E and D so that RR changes from 5 to 3.
The disease can be considered the alteration of this system, being the representation of an imbalance which is expressed initially as functional impairment, sometimes reversible [ 2].
The influence of TS on the efficiency of CCR hydrolysis and on the adsorption and recovery of cellulolytic enzymes was detected by considering the alteration of the glucose yield, protein concentrations, and enzymatic activity in the hydrolysate.
The inference that pain catastrophizing and subsequent fear-avoidance behaviours may influence the compliance of FMS patients towards exercise programs, justifies considering the alteration of pain catastrophizing in the management of FMS [ 14, 15].
The inference that pain catastrophizing is a key predictor of poor compliance in FMS patients, justifies considering the alteration of pain catastrophizing in improving compliance towards exercises in FMS patients.
We considered the alterations in KEGG pathways as most significant if the adjusted KS test p-values derived from both orderings (by the pair wise test statistic and SVD) were less than 0.01 in at least one data set normalized by either the MAS5.0 or GCRMA+LVS algorithm, or if the adjusted p-value was less than 0.05 in both data sets.
Considering the alterations of JNK and ERK1/2 activations in Gstp1/2 −/− mice, we have also investigated the expression of genes induced by the cellular redox status and hemodynamic changes that arise after liver resection.
Considering the alterations described above, our hypothesis was that although stable and not presenting swallowing complaints, patients with COPD should present signs of altered swallowing (i.e. larger amounts of valleculae residue and alterations in swallowing transit times) when compared to their healthy pairs.
To clarify the thermotolerant mechanism of K. marxianus, it is necessary to consider the expressional alteration of whole genomic genes at high temperature.
Should the unthinkable happen and Mitt Romney actually wins today or even if the Republicans are allowed to steal the election, consider the necessary alterations to that hoary standard, the Pledge of Allegiance.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com