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Thus, we consider that the expression levels of these six miRNAs in the PBMCs of CHC patients act as significant risk biomarkers for the development of CHC.
Based on the results of previous studies and our study, we consider that the expression of ADAR2 mRNA is not significantly altered in gliomas.
So it is very difficult at the moment to consider that the expression of HBME-1 and Gal-3 markers is linked to tumor transformation.
An obvious way to study the consistency of a regulatory network with expression data is to consider that the expression changes of some network products have to be explained by the connections existing in the network.
Thus, we consider that the expression level of miR-122 in PBMCs could be used as a diagnosis marker of CHC but not to monitor amplification of the virus.
Because this study was performed in vivo, we consider that the expression of the catabolic genes may have led to degradation of the existing matrix and subsequent proliferation and synthesis of new matrix in the limited articular cartilage space.
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Moreover, the very low number of differentially expressed genes was surprising considering that the expression of SUN was quite high in the lines carrying oval-shaped fruit at the time points sampled.
For the purpose of this example, we ignore that information, and consider that Notch inhibits the expression of the Delta ligand, as it is the case in Drosophila when building our original model.
Considering that the expression level of TNRC6C is relatively low in HeLa cells compared to TNRC6A and TNRC6B (Yao et al., 2011), only TNRC6A and TNRC6B were downregulated using a mixture of siRNAs (TNi) targeting each to serve as a positive control.
However, it also needs to be considered that the expression level of waspΔVCA in the mouse transgenic model approximates the normal wasp expression level.
It is also considered that the expression of many genes and proteins is involved in the mechanism of antibiotic resistance expression of bacteria based on previous studies [ 26– 29].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com