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At this stage, the most simple hypothesis supported by our data is to consider that expression of at least one gene is required under anaerobiosis to promote polar localization.
We consider that expression of these proteases and their inhibitors at mRNA and protein level could represent a valuable instrument in the prognosis of this type of tumor, which is one of great public health concern.
On the basis of the past reports about MK expression in ageing-related diseases, it is natural to consider that expression of MK is elevated in the presymptomatic stages of diseases, such as asymptomatic cerebral infarction, asymptomatic ischemic heart diseases, and a pathological prestage of Alzheimer's disease.
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This finding, however, was not surprising considering that expression levels of protein necessary for the induction of tolerance may not be detected by the methods we chose.
As the α5β1 integrin is an important adhesion receptor for fibronectin (Zhang et al., 1993), we considered that expression levels of DDR1 may affect β1 integrin-dependent adhesion.
It should also be considered that expression of X-linked genes in spermatids will not only require alleviation of MSCI but also more specific post-meiotic transcriptional regulation.
For the interpretation of transcriptomic results, it has to be considered that expression profiles represent one regulatory level in the response to environmental changes and thus do not necessarily reflect the changes of other regulatory levels, e.g. protein abundances and activities.
An obvious way to study the consistency of a regulatory network with expression data is to consider that the expression changes of some network products have to be explained by the connections existing in the network.
Based on the results of previous studies and our study, we consider that the expression of ADAR2 mRNA is not significantly altered in gliomas.
So it is very difficult at the moment to consider that the expression of HBME-1 and Gal-3 markers is linked to tumor transformation.
Thus, we consider that the expression levels of these six miRNAs in the PBMCs of CHC patients act as significant risk biomarkers for the development of CHC.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com