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So, to consider such a trial, researchers would first need to demonstrate with data from young adults (18 to 20 years old) that the risks are likely minimal for older teenagers.
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While a placebo-controlled trial in vaccine refusers may be considered, such a trial is unlikely to meet substantial methodological barriers regarding trial size and generalizability.
In considering such a trial, however, one would need to weigh the objective of demonstrating only a potential modest benefit in mortality reduction against the potential safety concerns and the costs of epoprostenol treatment.
Spitzer refused to consider such a move.
Mr. Edwards, who deposed Monica Lewinsky during the impeachment of President Bill Clinton, was considered such a skilled trial lawyer that others in the profession would rush to catch his closing arguments.
The first pillar boxes in the British Isles were erected in Jersey in 1852 in a trial that was considered such a success that shortly afterwards boxes appeared across mainland Britain.
During his own trial four years ago, Lehder was considered such a dangerous narco-terrorist that he sat shackled in the courtroom in Jacksonville, Fla.
The second trial considered in support of the drug was a withdrawal study, and FDA said its division of psychiatry products had not previously considered such a study as one of the primary pieces of evidence for an approval.
Scotland is currently considering such a move.
Although underpowered trials are viewed as unethical by many people, others consider such trials ethical in that some evidence is better than none 6 22 and such trials could even produce more information than larger studies.
For trials that began enrolment prior to this date, the ICMJE member journals originally required registration by 13 September 2005. 1 However, beginning on 13 September 2005, ICMJE journals will consider such trials only if they are adequately registered before journal submission. 2 Trials are only eligible for publication in ICMJE journals if registered correctly.
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