Three compounds gave IC50 values in the low micromolar range (Table 1) and were considered of interest for further study.
These hypotheses imply that a new drug would be considered of interest for further study if either the response rate, r, was sufficiently high or the early progressive disease rate, epd, was sufficiently low; it is not necessary that both outcomes occur.
If, despite this variability, one wants to give recommendations for clinically relevant effects that can be considered of interest for antiemetic trials studying the treatment of PONV, one may consider two scenarios using the lower and the upper bound of the 95%-confidence interval of the pooled incidence of PONV recurrence.
Based on a steep dose response relationship for especially alkylating agents on tumour cell survival, high-dose chemotherapy was considered of interest for the treatment of solid tumours.
Inhibitors of LIM kinases are considered of interest for several indications, including elevated intraocular pressure (IOP), cancer, or infection by HIV-1.
The major environmental factors considered of interest for this experiment were temperature, pH of the media, and agitation (rpm), which were optimized using Response Surface Methodology.
The concentration value found for PhTES is much lower (0.66 mg/ml) but, if especially compared with that of most the reported data[11, 22, 26, 27], it can be considered of interest; for instance, for the preparation of polymer composites, in which an even lower concentration of graphene might result in peculiar final properties of the resulting material[16, 18, 33 35].
Nevertheless, these QTL effects are too weak to be considered of interest for further research.
With regard to vaccine exposure, the 12 weeks preceding the hospitalisation were considered of interest for all non-influenza vaccines.
As the expression of STn is highly restricted in normal tissues (Julien and Delannoy, 2003), this antigen has been considered of interest for the development of anticancer vaccine.
Due to the fact that this category also has more genes represented in the yeast genome, this group was not considered of interest for this analysis.
