As a consequence, the RPA score can be a useful tool when considering indications for surgery.
Endothelial dysfunction and secondary corneal edema were traditionally considered indications for penetrating keratoplasty (PKP).
Claudication and critical limb ischemia (CLI) are symptomatic manifestations of PAD and are often considered indications for revascularization therapy with either lower extremity bypass surgery (LEB) or peripheral endovascular intervention (PVI).
Out of eight significant factors, SCS outcome was omitted in the multivariate analysis because SCS outcome is not yet known on considering indications for the surgery, although SCS outcome had a statistically significant correlation with the number of recurrent tumours (P<0.001, χ test).
Though there are no strict guidelines regarding when endoscopy is indicated, ingestion of larger amounts of corrosives, persistent symptoms, as well as suicidal intention are considered indications for endoscopy in the absence of a third degree burn of the hypopharynx [ 21, 22].
When considering indication for use and regimens for administration, very few differences were observed between the pre-specified subgroups.
Considering indication for use, no significant subgroup interactions were identified, expect for when considering arm discomfort, which suggested a possible increase for women receiving treatment for fetal neuroprotection (compared with women receiving treatment for pre-eclampsia).
When considering indication for use, the subgroup interaction tests for the majority of outcomes were non-significant, indicating no differential effects according to the different reasons for administration (see Table 1 for effect estimates for indication for use subgroups and Additional file 5 for forest plots).
This study did not consider new indications for existing licensed and marketed drugs.
We consider the indications for each and the possible pitfalls.
