These aspects are important when considering castration-resistant prostate cancer, a malignant tumor posing difficult therapeutic intervention.
Of course, most men would not consider orchiectomy (castration), particularly given the consequent loss of masculine attributes, including genital hypotrophy, loss of libido, gynecomastia and development of a more feminine body fat distribution pattern [ 40].
The episode comes the same day as former Mayor of London Ken Livingstone said he would be willing to consider the chemical castration of paedophiles.
Consider also that castration has been in evidence for millennia, some of it as ritual ceremony (though not as widespread as the later custom of female genital mutilation) that contributes to the genesis of art.
While centuries of knowledge on the issue of castration (consider stories of the Mughal-era eunuchs who protected harems but had affectionate relationships with each other) would suggest that it does not entirely remove human sexual instincts, it certainly dramatically reduces the sexual urge that in the case of sexual offenders is apparently uncontrollable.
Patients were considered resistant to castration if they had three consecutive increasing PSA tests separated by a minimum of 2 weeks and PSA ≥1.0 ng/mL for the last two measures.
To any viewer who thinks "Sons of Anarchy" is too violent, consider the bright side: At least the castration scene got … um … deleted.
Another study conducted in Ghana also showed that 39% of the people related vasectomy with castration and considered it a shameful procedure [ 8].
Furthermore, 68.4% and 30%, respectively, did not reach castration levels, considering a testosterone cutoff ≤ 20 ng/dL; the difference at this cutoff was statistically significant.
With respect to testosterone-lowering treatment options, orchiectomy (bilateral surgical castration) is considered the state-of-the-art treatment for androgen deprivation therapies (ADT).
