Our interest in ALDH detection relies on the consideration that FCM based ALDH activity assessment is exploited in order to evidence a conserved stem cell function, rather than to merely identify a stem cell antigen [ 16].
Thus, the pro-apoptotic roles of p53 are conserved between stem cells and differentiated cells.
The ability of the implant coatings to conserve a healthy stem cell pool is promising to further endorse the fabrication of new osseointegration implant designs with extended lifetime.
Our findings establish key evolutionarily conserved mechanisms of human stem cell aging.
Therefore, Pumilio proteins appear to have conserved functions in regulating stem cell behavior.
SLAM family markers are conserved among hematopoietic stem cells from old and reconstituted mice and markedly increase their purity.
Yilmaz, O.H., Kiel, M.J. & Morrison, S.J. SLAM family markers are conserved among hematopoietic stem cells from old and reconstituted mice and markedly increase their purity.
Importantly, we show that this mechanism is conserved in evolution and across stem cell types.
The age-dependent decline in satellite cell number and activity was linked with defects in Notch signalling, an evolutionarily conserved pathway involved in muscle stem cell function.
Drosophila neuroblasts have served as a model system for identifying conserved signaling pathways that regulate stem cell proliferation and quiescence (Ebens et al., 1993; Datta, 1995; Britton and Edgar, 1998; Doe et al., 1998; Egger et al., 2008; Tsuji et al., 2008; Sousa-Nunes et al., 2010; Homem and Knoblich, 2012; Weng and Cohen, 2012).
Here we show that the moss Physcomitrella patens Cold-Shock Domain Protein 1 (PpCSP1) regulates reprogramming of differentiated leaf cells to chloronema apical stem cells and shares conserved domains with the induced pluripotent stem cell factor Lin28 in mammals.
