A short audio signal recorded at the given location is used to synthesize a new arbitrary-length signal, while conserving location-specific characteristics of the source audio.
Here, we propose that the identification of a phosphosite in an evolutionarily conserved location, as observed in three different organisms, provides strong evidence for a conserved, biologically significant phosphorylation site.
We have recently reported a novel strategy for the design of non-natural allosteric-inhibition sites in PTPs, in which a tricysteine moiety is engineered within the PTP catalytic domain at a conserved location outside of the active site.
Figure 1(A F) shows the highly conserved location of metals and substrates bound at the active site as well as the spatially conserved metal binding residues in various proteins (See legend for details).
Because motif loss and gain are likely to be accompanied by changes in motif content and spacing [ 30], we restricted our comparison to motifs consistently present in the regulatory region of the orthologous genes in the two species, rather than considering only motifs with a conserved location within a particular promoter.
The genes of the second and third group showed a tightly conserved location of the sequences encoding the tetrapeptide active sites, which in wheat were 200 bp from the end of the first exon and 120 bp from the end of the tenth exon; the amino acid sequences of the tetrapeptides were less conserved, especially among proteins encoded by the genes of the third group.
These two flanking genes appear to have conserved locations upstream and downstream of the MAT genes in other species from section Flavi [ 26].
Alignment with the thrombospondin type 3 repeat sequences of human thrombospondins (Fig. 2) demonstrated that the RGD and KGD motifs found in N. vectensis thrombospondins are in phylogenetically conserved locations.
Otherwise, B. napus inherited kelch motif ACBPs from ancestor conserving chromosomal location, emphasizing preserved synteny block region.
SAS-6 aggregation after activation and localization at flagellum tips suggest a conserved BB location (Fig. 2) and fits with the structural defects found in the knockouts.
While the position of many tRNA genes was conserved, the location of trnA, trnK, trnP, trnT, trnL CUN, trnL UUR, and trnV was more variable across the four genomes.
