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Laroche et al. [ 6] showed that wt-SAK immunogenicity can be significantly reduced by site-directed mutagenesis to eliminate antigenic epitopes present within the protein sequence, while conserving its activity.
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In the presence of drug concentrations that inactivate native PBPs through irreversible acylation, PBP2a conserves its transpeptidase activity allowing cell-wall biosynthesis to continue15.
By binding to Apo-A1, Hpt prevents damages from hydroxyls radicals and allows Apo-A1 to conserve its stimulatory activity on the LCAT [ 30].
First, yeast Emg1 bearing the equivalent mutation of the BCS protein conserves its rRNA methyltransferase activity in an in vitro methylation assay [20] despite causing a reduction in cell growth rates.
There is a growing demand to find an effective extraction process of sulfated polysaccharides from brown algae to conserve its structure and biological activity.
The bioelectrode exhibits excellent stability over time, conserving more than 50% of its activity after one week.
The proteolytic domain is highly conserved between different TTSPs and its activity is dependent on the presence of a 'catalytic triad' that includes the amino acids His, Asp and Ser.
Maybe this protein has conserved GTPase activity and as it evolved to Rab2A (crown position) it acquired specific prenylation activity (Fig. 7c).
For example, if enhancer activity is highly conserved, then this activity would be detected in all species where the underlying DNA was alignable.
Compared with controls, patients with CRF showed preserved mitochondrial content, conserved respiratory activity, intact enzyme activity of MRC complexes, and no increase in lipid peroxidation.
A Chloro substituent at the 2-position of 1a, compound 1d, retained potency against DNMT1, while N6 alkylation, compound 7a, conserved DNMT3b2 activity.
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