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Simultaneously, the energy conserving complexes I, III and IV build up a trans-membrane electrochemical gradient by coupling the electron transfer activity to proton translocation from the matrix to the outer side of the inner mitochondrial membrane.
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Although NetAligner employs more lax criteria to introduce conserved interactions, it also yields a lot of false positive conserved interactions, which reduces its performance of detecting conserved complexes.
GASOLINE took 110 seconds to complete the task and returned many known conserved complexes with a high degree of topological conservation (ISC between 80 and 90%).
This result shows that those conserved complexes are indeed enriched by common and specific functions.
Further studies should address how E-cadherin and ß4 integrin interact with these conserved complexes.
This process is recursively implemented on those components and finally outputs conserved complexes.
Condensins are conserved complexes that play fundamental roles in chromosome dynamics throughout the cell cycle [ 22].
Alignment-graph-based methods [ 18– 21] usually take two steps to identify conserved complexes.
FP (false positive) is the number of predicted conserved complexes that fail to match with known protein complexes.
Condensins are evolutionarily conserved complexes, which promote chromosome compaction, organization, and segregation during mitosis and meiosis [ 22].
Candidate subgraphs with highest scores are detected as conserved complexes, using a similar heuristic as in [ 78].
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CEO of Professional Science Editing for Scientists @ prosciediting.com