NSS family members are an ancient group of highly conserved integral membrane proteins with characteristic twelve transmembrane pass domains.
No predicted functional motifs in this highly conserved integral membrane protein, other than the transmembrane domain, have been identified.
5S rRNA is a structurally conserved, integral component of the ribosome large subunit in all organisms and is essential for ribosome function [27] [29].
One candidate is Ndc1, an evolutionarily conserved integral membrane protein that is present at the pore membrane of both SPBs and NPCs (Chial et al., 1998).
In 2006, it was renamed Translocator Protein 18 kDa (TSPO) to better represent the emerging understanding of a family of highly conserved integral membrane proteins found from Archaea to plants and humans, with a broad spectrum of functions, including steroid and porphyrin transport and regulation of apoptosis, inflammation, metastatic cancer, and cardiovascular diseases.
This summary doesn't pretend to be an exact copy of Sun Tzu's Art of War, but it conserves its integral characteristics.
Recent developments in finite-volume methods provide the basis for new dynamical cores that conserve exactly integral invariants, globally as well as locally, and, especially, for the design of exact mass conserving tracer transport models.
The seven proteins of this family are highly conserved and integral to a number of important cellular activities.
Even in 'Ca .P. mali' the highest number of RNA-Seq reads was assigned to a conserved hypothetical integral membrane protein [ 18].
The activation loop in mTOR is similarly held in a catalytically competent conformation via interactions with a highly conserved and integral ∼35 residue FATC domain, which is stabilized through packing interactions with a ∼40 residue insertion in the C-lobe termed the LBE (Yang et al., 2013).
The first two proteins are conserved membrane-integral nucleoporins (Cut11/Ndc1 and Pom152/GP210) and form a stoichiometric subcomplex in both human and budding yeast, thereby constituting an internal membrane ring (Madrid et al, 2006; Mansfeld et al, 2006; Stavru et al, 2006; Alber et al, 2007a, 2007b; Galy et al, 2008).
