Exact(4)
CLDN13 phylogenetically groups with its genomic neighbour CLDN4, a conserved tight junction protein with a putative role in epithelial to mesenchymal transition, suggesting a recent duplication event.
The CRDs all show a highly conserved tight fold, with two anti-parallel β-pleated sheets forming a sandwich-like structure (Rini and Lobsanov 1999).
Unlike for Tfpb that are more heterogeneous Flp that are assembled by the conserved tight adherence (Tad) locus are an exception (Tomich, Planet and Figurski 2007)—genes are conserved 'en bloc' for Tfpa or T2SS with similar genetic organizations.
G188 is positioned at a conserved tight loop linking α-helix 2 with the three-stranded antiparallel β-sheet that forms the central part of the domain.
Similar(55)
If the introduced mutations do increase cellular fitness, the mutated sequence is likely to be conserved and a tight regulation of the availability of such sequence will prevent undesired aggregation and keep functional aggregation under control.
It appears to account not just for the "flexibility" functions mentioned above, but also for many of the characteristics traditionally associated with disordered regions, such as strong association with signaling and regulation processes, rapid sequence evolution, the presence of short linear motifs (which are themselves conserved, see below), and tight regulation (see section 8).
For paranoid and thrifty travellers, it's a way to both add an extra layer of security at open public Wi-Fi hotspots like those you'll often find in airports, and conserve data on tight roaming plans, too.
Further, as suggested above the conserved acidic residue could allow tight association with certain types of lipids and alter the permeability of the plasma membrane to deleterious substances.
A propensity for tight bending is a conserved feature of satellite DNA, and it is thought to contribute to the structural stability and compaction of centromere chromatin [ 12- 15].
They rouse the rest of the bees in the hive, who have conserved energy by shutting down in a tight scrum, and lead them to their new home.
Given the tight constrains in the definition, conserved TFBSs were scored in much smaller numbers than in the Clover analysis.
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