Sentence examples for conserved the key from inspiring English sources

Despite the fact that the co-crystallized pyrrolidine conformation of enalaprilat is almost planar and hard to be predicted, the pyrrolidine conformation produced by Maestro preparation was – to a certain extent – comparable to it and conserved the key polar contacts of enalaprilat's carboxylate group with the surrounding polar residues after docking.

Notably, although carotenoid-binding Lys-255 (Lys-216 for BR) and proton-releasing Arg-109 (Arg-82 for BR) are conserved, the key active site residues in typical proton-pumping rhodopsins (Asp-85 and Asp-96 for BR) are replaced by Asn-112 and Gln-123 (fig. 2 A), suggesting that this protein is functionally unique.

This response is highly conserved, reflecting the key role of phase 2 detoxification reactions in protecting cells against ROS-induced damage.

Whether 'evolutionary' in nature or not, we postulate that the relative paucity of T cell epitopes (both novel and conserved) in the key antigens of emerging H7N9 will have serious consequences for human immune response and vaccine design.

In this postulated mechanism, the fully conserved Phe49 is the key residue that couples conformational changes of the dinuclear copper site into movements of the first domain.

Among the conserved receptor residues, the key regulator of acid pH-dependent pore formation was Y119 of ANTXR2, which occupies a planar position between domains 2 and 4 of PA (Fig. 4A) and appears to make hydrophobic and H-bond interactions with both domains.

Among these, conserved genes are the key regulators of S. cerevisiae response to weak acid stress Haa1, War1 and Rim101.

Since the insertion of the VSV-G tag into the KE strategically conserved a key epitope for an existing KE-specific MAb (SAR1), cells expressing the various Env constructs were also tested for reactivity with this native sequence-specific MAb.

In addition, the arginine conserved in key active site of PhoAs is deleted in SPAP.

Coral Triangle could be key to conserving the world's reefs as Indonesia corals survive worst coral bleaching event in history.

The domains of the SjIRs have all the highly conserved key motifs described in SmIRs for tyrosine kinase activity [41] and these are presented in detail in Figure S1B.