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Although the repeated RNAPII CTD sequence of yeast and human cells is highly conserved, the human CTD is approximately twice the length of the yeast CTD.
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The database contains gene-associated motifs that are conserved across the human, mouse, rat and dog genomes, including conserved transcription factor binding sites, conserved anonymous motifs and conserved recognition sites for miRNA [ 14].
Such sequences and the overall promoter architecture are highly conserved in the human gene.
Murine NEU1 contains 4 N-glycosylation sites, 3 of which are conserved in the human enzyme.
The panAR-siRNA targets a sequence conserved between the human and mouse AR mRNAs.
We show that these interactions are conserved in the human orthologs.
These blocks are also conserved in the human homologue of Slk19, CCDC73 (unpublished data).
The intron-exon structure of the gene is well conserved with the human homologue PRDM14 on human chromosome 8.
The whole genomic cluster containing mir-200c and mir-141 is well conserved between the human and mouse genome.
A total of 373 pY events (68. 9%) in this data are conserved in the human proteome (Figure 1).
Two of these three sites are highly conserved in the human and mouse genomes (SI. Figure S4b).
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