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Such an analysis assumes that natural selection has conserved the functional gene's sequence so that the modern sequence of the reading frame represents the source sequence of each of the pseudogenes.
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Conversely, circular permutations of IL-1β conserve the functional folding route as well as the agonist activity.
Complex rearrangement of the position of nucleotides, the position and size of loops, and the length of stems might be another mechanism to conserve the functional structure of an rRNA gene.
This difference most probably depends on whether the rice plant inherently conserves the functional OsHMA3, which is a membrane transporter protein involved in Cd storage in root vacuoles.
This gives rise to the conclusion that conserved N-termini in different Pti1 sub-families are evolutionary conserved indicating the functional relevance of this protein domain for proper biological function.
However, the motif sequences characteristic to OR genes such as the MA(Y/F DRYVAIC (single-letter amino acid notation) motif [5], [7] were well conserved among the functional OR genes identified in this study.
The above inference is also supported by the fact that NRKe and Xa3/Xa26 belong to a tandem clustered R gene family; some amino acid sites of LRR domains encoded by the genes in this family are subject to positive selection, whereas the kinase domains encoded by these genes are evolutionarily conserved, suggesting the functional constraint of the kinase domains in this family [ 9].
The observed correspondence between Dichaete and Sox2 target genes show that these proteins are not only conserved at the functional level when assayed in mutant rescue experiments but also, remarkably, at the level of the gene regulatory networks they control in the fly and mouse nervous system.
If desert ecosystems are to provide these goods and services, the occupants and managers of the lands in arid regions will have to adopt management strategies that conserve the desired functional and structural attributes of the ecosystems and landscapes within a region.
Although one of the two copies of cpsA, recG, glyS, and ftsK is pseudogenized by IS insertions, the rest of the genes conserve the two functional copies (fig. 5 A), indicating that their retention could be advantageous for the organism fitness.
Our results show that, in the absence of hunting, even the most intensively logged forests can conserve the abundance and functional effects of mammals.
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