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While the hydrophobic character at W626, L625 and W463 is again conserved, the central methionine is replaced by a glutamic acid, making it highly unlikely the two acidic side chains could pack closely together.
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The FxYP sequence of PAM2L (red box) is conserved in the central part.
Although flg22 Lso possesses amino acid D42, only two other amino acids are conserved in the central RINSAKDDA motif.
The human osteosarcoma cell lines MG-63 and U-2OS were obtained from the ATCC (Rockville, MD) and conserved in the central laboratory.
Structural analysis revealed that introns are highly conserved in the central region of the gene, and R2R3-type MYB proteins usually have two introns at conserved positions.
The PII-GlnD system has been conserved as the central control unit in nitrogen metabolism and glutamine signaling in bacteria [ 7].
A TQxxΦWΦxζ α-helical motif, where x is any residue (previously TQxA I/V W [ LinketWinnebeck et al., 2014]) is conserved in the central region of most, though not all putative TEDs.
Hallmark features for both classes of plant formins can be identified already at the level of amino acid sequence in the C-terminal portion of the FH2 domain, which is less conserved than the central area around the G-N-X-M-N motif (see Additional file 5).
Of the uric acid double ring, the molecule conserves the two central carbon atoms and an ureido group; two other nitrogen atoms had been released as urea or ammonia in earlier steps of the pathway.
Although glycolysis is highly conserved, this central metabolic pathway is modified extensively during spermatogenesis.
Interestingly, despite being within the conserved central region of the genome, the TMPK gene orthologues occur within a region of PEPV and FeP2 that is highly variable compared to FWPV.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com