Sentence examples for conserved the binding from inspiring English sources

Although the SusD scaffold is structurally well conserved, the binding pockets for saccharide ligands exhibit a larger degree of plasticity [ 34, 35].

Interestingly, we found that the co-binding peptide provided ~ 2 kcal/mol of stabilization as shown by their respective Docking Score (DS) and also proceeded to conserve the binding mode orientation of abacavir [44].

Although the proline-rich region is not always conserved, the SH3 binding domain is conserved in the dsh-1 orthologs of all taxa, but is absent in nematode mig-5 orthologs.

However, the seventh binding site, notated in Figure 4 as bs2, is poorly conserved and the binding site peak probabilities do not exceed 50%.

This was attributed to the reduced level of cross-linking, which is required to conserve the imprinted binding cavities during polymerization.

However, while the C. elegans sequences conserve the heme-binding histidine residue, they lack two critical cysteine residues required for NO activation in mammalian sGC β-subunits [ 28].

With the p-value cutoff of 0.01, we calculated the proportion of the significantly conserved binding sites among the over-represented putative binding sites.

This is consistent with the finding that the c subunit of the F1FO ATP synthase does not have the conserved Na+ binding motif.

FTO and ALKBH5 belong to the AlkB family owing to the conserved iron binding motif and α-ketoglutarate interaction domain [51 54].

For miR-181a/b, the minimum free energy value of the hybrid between miR-181b and the conserved binding site on the PDCD4 3′-UTR is -17.4 kcal/mol and is lower than that of miR-181a (−16.2 kcal/mol), suggesting that miR-181b may bind more tightly to PDCD4 3′-UTR than miR-181a.

These inactive states comprise the DFG-out state, in which the conserved phosphate binding motif "DFG" changes conformation opening a large allosteric binding pocket.