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The alignment of protein sequences of Ac-AChBP with human α7 nAChR subunit shows the amino acid sequence identity is 26%, but the sequence similarity is 42.9%, and many residues among them are conserved such as the conserved tryptophan (W) in the ligand binding site [ 1].
Additionally, by revealing which interactions are evolutionarily conserved, such comparative studies will greatly enhance our ability to interpret the conserved biological functions of the interacting proteins, and also the computational analysis of high-throughput protein-protein interaction datasets [ 10].
A similar conservation pattern is observed in other metabolic maps classified as moderately functionally conserved, such as the pathway for glycerophospholipid metabolism (00564).
The second can be addressed by designing drugs that interact with portions of the viral machinery that are evolutionarily conserved, such as enzyme active sites.
Other positions also appeared to be highly conserved such as G19, L34 and A78, but were not common properties to all sHSPs.
Key components of the assembly and export of Group 2 and Group 3 capsules are highly conserved (such as KpsD, KpsC, KpsU, KpsS, and KpsM), making it theoretically possible to identify small molecules that are capable of inhibiting the biogenesis of a variety of capsules that differ significantly in composition and antigenicity.
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Parasite conservation presents a critical conundrum: to conserve such bloodsuckers and disease-spreaders is to explicitly conserve death and sickness.
And infectious diseases experts say they believe hospitals already have an incentive to conserve such drugs.
Hence more attention needs to be given to conserving such species within broader regional landscapes.
A building block analysis demonstrates how this arises and reveals an approach, based on bond-type substitution and molecular replacement, to conserving such features.
"In this context, we would expect the Scottish government to be stepping up to do all it can to conserve such an important asset.
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