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Here, we show that the proliferating cells in sporocysts express many conserved stem cell genes.
Our interest in ALDH detection relies on the consideration that FCM based ALDH activity assessment is exploited in order to evidence a conserved stem cell function, rather than to merely identify a stem cell antigen [ 16].
The germinative cells of E. multilocularis larvae are a morphologically homogeneous population of undifferentiated cells, which however show heterogeneity at the molecular level in the expression of conserved stem cell regulators such as nanos and argonaute genes (Koziol et al. 2014).
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Recent findings strongly suggest the importance of cell isolation method, particularly when using enzymatic digestion that lowers proteolytic contamination, in conserving stem cell function in skeletal muscle [28].
Thus, the pro-apoptotic roles of p53 are conserved between stem cells and differentiated cells.
The ability of the implant coatings to conserve a healthy stem cell pool is promising to further endorse the fabrication of new osseointegration implant designs with extended lifetime.
Our findings establish key evolutionarily conserved mechanisms of human stem cell aging.
Therefore, Pumilio proteins appear to have conserved functions in regulating stem cell behavior.
Canonical Wnt signaling is highly conserved and, importantly, regulates stem cell dynamics in many tissues, including the breast [ 23].
The transcription factor Nrf2, for example, has an evolutionarily conserved role in regulating stem cell quiescence, including of ISCs in Drosophila (Biteau et al., 2011) and of HSCs in mice (Tsai et al., 2013).
Since we previously demonstrated that mES cells promiscuously express a large variety of functional and tissue specific cell surface proteins at the protein level [19], it is interesting to ask whether this promiscuous pattern is conserved between pluripotent stem cells and germ cells from different species.
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