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PhastCons (Margulies et al., 2003) is a phylogenetic 2-state HMM which predicts if nucleotide positions in a multiple alignment are in an evolutionarily conserved state or not.
Alignment sites (segments) are predicted as being conserved if they are significantly more likely to have been generated by the conserved state of the HMM.
A conservation score, the posterior probability of being in the conserved state, was also calculated.
The phastCons program computes conservation scores based on a phylo-HMM with two states (conserved and non-conserved regions) that correspond to the posterior probability that a given alignment column is generated by the conserved state of the phylo-HMM [ 48].
RJ metagenome showed the higher number of microbial isolates, which is consistent with its most conserved state and higher diversity.
The score of each site is the posterior probability that the site is in the conserved state of the phylogenetic hidden Markov model.
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Apple's invention would not create a persistent hotspot in the same way that sharing via Bluetooth or Wi-Fi from your iPhone does currently; instead, it would check in periodically, seek out updates from iCloud, grab push notifications, messages, news, weather and other data and then shut down again, returning to a power conserving state.
Changes consistent with the suppression of cytoskeletal dynamics provided further evidence that cold-adapted cells are in an energy conserving state.
In the GTP-bound state, two functionally conserved regions, switch I and switch II (Fig. 1B), undergo a conformational change enabling RRAS to bind to and activate effector proteins.
The inactive states of kinases are much more diverse than the well conserved active state of kinases [6,21].
Sleep is an essential and evolutionarily conserved behavioral state whose regulation remains poorly understood.
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