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Embryos do not show a highly conserved stage with a common set of morphological features [48].
They also show that the stage may be the most developmentally conserved stage since the evolution of ancestral vertebrates, making it a candidate for the phylotypic stage.
In insects, this conserved stage was first called Körpergrundgestalt, or the form-building stage by Seidel (1960, as discussed in Hall 1997).
Therefore, while many researchers argue that a phylotypic stage does exist, its occurrence is mid-development, and species arrive at this conserved stage via dramatically different routes (Hall 1999; Newman 2011; Raff 1996).
Comparative embryology of various animal groups has suggested the idea of a conserved stage in embryogenesis.
Here we describe three pleiotropic mutations with large effects on a novel trait, butterfly eyespots, and on a conserved stage of embryogenesis, segment polarity.
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This latter point is especially important to the testing of the phylotypic stage hypothesis: our method allows us to define constrained or conserved stages in each organism, and thus to compare data among various vertebrate embryos.
Conserved stage-specificity and localization of TBX1 expression between mouse and human embryos was demonstrated (ISH; Fig. 2A,A′).
This morphologically conserved intermediate stage of development, preceded and succeeded by developmental diversity, has been called the developmental hourglass (Duboule 1994; Hall 1997, 1999; Raff 1996).
PCR primers were based on the published sequence of the highly conserved [24], stage specific [25] P. falciparum 18S ribosomal RNA gene.
This provides support for a 'developmental hourglass' model of divergence of gene expression in Drosophila resulting in a highly conserved pupal stage.
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