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R280 is a highly conserved site and forms an ion pair with another conserved site E208, which is also included in the γ-shaped network.
Briefly, if the variant was located at a fully conserved site or led to a nonconservative substitution at a conserved site, it was considered deleterious.
(Os08t0122800-01); Kringle, conserved site domain containing protein.
RabGAP/TBC domain containing protein 1.33 OsSGR0532000 OsSGR, TonB box, conserved site domain containing protein 1.62 Os04g0600300 OsAOX1b, Homodimeric diiron-carboxylate protein, Cyanide-resistant respiration in mitochondria 1.79.
Taken together, the above results indicate that HK20 recognizes a highly conserved site within the HR-1 region of gp41.
The electrostatic repel between the highly conserved site D166 and the phospho-residue in product could serve to facilitate the phosphoproduct dissociation [59].
Ro60 binds to a highly conserved site on the lower stem of Y RNAs [11], [12], [29], while La interacts with the 3' polyuridine tail [28], [29].
One of these enzymes was the NAD-dependent isocitrate dehydrogenase (IDH, E.C. 1.1.1.41), in which we identified a novel amino-acid substitution in a phylogenetically conserved site.
Each poorly conserved site has been examined and a reason postulated.
The entropy is zero for a completely conserved site and increases with variability.
We used phyloP new >0.95 as a rule to predict conserved site [Siepel et al., 2006].
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