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This conserved rate of HER2 positivity among IBC patient cases occurs even in areas of the world with historically higher incidence of the disease, such as Tunisia – where IBC accounts for approximately 6% of all breast cancer (contrasted with 2.5% IBC in our study) [ 26, 27].
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Field cancerization effects as well as isolated tumor cell foci extending well beyond the invasive tumor margin have been described previously to account for local recurrence rates following breast conserving surgery despite adequate surgical margins and breast radiotherapy.
The most conserved intronic motif (GTNAGT, Additional file 1, Table S1), corresponding to a splice donor motif, is both abundant (6648 instances) and well conserved with C.R. (conservation rate) equal to 37%.
Comparing genome size estimates between three species, Pinus pinaster, Pinus strobus and Pinus palustris, Echt and Nelson [ 50] showed that pines have similar genome lengths, suggesting a highly conserved genomic rate of recombination across species.
The breast conserving rate was 68.2%, and most of these were treated with radiotherapy.
Secondary endpoints include pathologic complete response rate, breast conserving rate, change in Ki67 expression, breast density change, and toxicity profile.
Low-complexity reception and interference suppression are essential in multiuser mobile systems if battery power is to be conserved, data-rates improved and quality of service enhanced.
Therefore, we conclude that hub interactions are conserved at rates that are better than average, and the effect of hubs should be considered in subsequent analyses.
The conservation frequency differed a great deal among pair types in maize, where divergent pairs are conserved at rates close to half that of convergent or tandem pairs.
Interactions connecting proteins annotated with kinase activity (GO 0016301), a category that consists of 222 proteins, are conserved at rates of 14%/23%, but the sub category of protein kinase activity (GO 0004672) that contains 135 proteins are conserved at rates of 19%/29% which is higher than the average.
Breast conserving surgery rate was 39.1% (18/46).> -wrap-foot> Abbreviations: PD = progression disease; cPR = clinical partial response; cCR = clinical complete response; tpCR = total pathological complete response; bpCR = breast pathological complete response.
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