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The current major focus in leptospirosis research is to discover conserved protective antigens that may elicit longer-term protection against a broad range of Leptospira.
However, the insulin/insulin-like growth factor-1 (IGF-1) signalling (IIS) pathway and mammalian target of rapamycin (mTOR) signalling pathway are highly conserved candidates for protection against the effects of the ageing process [1], [2], [3], [4], [5], [6].
Evolution of the Arabidopsis POT1 proteins represents an extraordinary example of rapid neofunctionalization within the context of the otherwise highly conserved chromosome end protection machinery.
As an evolutionarily conserved mechanism for protection against excess acidification, cation H+ exchangers couple the transfer of H+ across biological membranes to the counter transport of monovalent cations such as Na+ or K+.
The 3D-structures of the relevant regions containing the conserved protection-inducing motifs were modeled using the HMMSTR Ab-initio prediction server [55], [56].
Several Caenorhabditis elegans genes that ensure the genomic integrity of the germ line are also involved in regulating lifespan although it is not known if this protection is conserved in higher organisms [ 8].
The positive correlation between secondary structure protection and functional importance of sites suggests that some sites might be conserved due to packing-protection constraints at the nucleic acid level in addition to protein level constraints.
To conserve those species, protection of wild lands will remain essential.
Because our country's grasslands receive very little legal protection, conserving much of the remaining prairie falls to individual landowners.
We proposed that all populations should be managed and conserved separately, especially for habitat protection.
These results highlight the importance of non-serotype-specific antibody responses induced using the highly conserved VP6 protein in heterotypic protection.
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