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Lectin and Toll receptors have related functions, both recognising conserved products of microbial metabolism [ 70].
However, there is a paucity of research on the potential physiological functions of these evolutionarily conserved products of the Aβ precursor protein.
In both developed and developing countries, many millions of livestock farmers, ranchers and pastoralists depend on grasslands and conserved products such as hay and silage and on a range of fodder crops for their livelihoods.
Our data demonstrate that within the X. bovienii species, there is diversity in the coding potential of bioactive molecules (Table 3, Additional file 10) and the regulation of some conserved products [ 5] (Table 2).
Subfunctionalization may explain why major and minor duplication products differ in their fate: 8/10 minor isoform duplications result in a rapidly-evolving and a conserved product, while 7/9 major isoform duplications result in two equally conserved products.
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Toll-like receptors (TLRs) recognize structurally conserved microbial products and mediate the initiation of inflammatory and immune defense responses [1].
ORF predictions were made using comparative genomics approaches (tBLASTx), searching for conserved gene products between closely related phages (14-1 vs F8, PNM vs phiKMV and ISP vs G1).
The protein sequences of highly conserved gene products (>95% identity) of B. burgdorferi, B. garnii, B. afzelii, B. valisiana, and B. spielmanii were aligned with ClustalW [34] (not shown).
In vertebrates Sin1 falls into a class of highly conserved gene products.
Autophagy is mediated by a set of evolutionarily conserved gene products (termed the ATG proteins) originally discovered in yeast [ 13].
Overall, many of these evolutionarily conserved gene products that are critical for DDR and DNA repair have been explored as potential targets for cancer therapy [7].
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