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This year's Hugh Sinclair Lecture was delivered by Leena Peltonen (Sanger Centre, Hinxton, UK), who described the unique properties of highly conserved populations for mining the genome for complex traits.
Conserved populations, such as Sardinians, displaying elevated rates of familial or sporadic amyotrophic lateral sclerosis (ALS) provide unique information on the genetics of the disease.
Conserved populations must be sufficiently large to allow for this.
Among those factors, the genetic architecture of conserved populations is little considered in current conservation strategies.
In conserved populations, we are interested in the conservation of alleles that come from native founders, as migrant alleles usually originate from non-endangered breeds.
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The two scenarios on genetic architecture were taken into account, namely, one conserved population with same allele frequency (AS) and another one with actual allele frequency (AA).
Genetic characterization of S. suis serotype 2 strains isolated from human patients with meningitis in southern and central Vietnam, showed a highly conserved population structure [2].
Dopaminergic diencephalospinal neurons (DDNs) are an evolutionarily conserved population of forebrain neurons that provide the primary source of dopaminergic (DAergic) innervation to the vertebrate spinal cord.
First, conservation managers with limited resources at their disposal typically need to conserve populations of several threatened species.
Understanding the factors regulating natural populations of entomopathogenic nematodes may provide insight into practices to conserve populations within production systems.
Retaining and managing forest remnants would be a more effective strategy to conserve populations of these species.
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