Our findings reveal novel conserved players in the oxidative stress response and suggest a broad cytoprotective role for MDT-15.
A similar role has been identified for the Arabidopsis putative ortholog, AtMKK6 [ 13], which suggests that MKK6s could be highly conserved players in plant cytokinesis and stem cell development.
A set of genes that were identified to be responsible for the asymmetric zygotic division of Caenorhabditis elegans, namely, par1 to par6 and an atypical protein kinase C (Kemphues, 2000; Kemphues et al., 1988), were subsequently found to be highly conserved players regulating the process of polarization from worms to mammals (Goldstein and Macara, 2007).
Of course, these league giants were conserving players Saturday because they have Champions League quarterfinals this coming week.
The primary PcG/trxG players are evolutionary conserved in all higher eukaryotes [ 7- 10].
DSB formation leads to activation of a complex DNA damage response (DDR), whose key players are highly conserved protein kinases, which include human ATM and ATR, as well as their Saccharomyces cerevisiae orthologs Tel1 and Mec1 (Gobbini et al., 2013).
The coaches' logic: players conserve energy and boost their aggression for a stronger athletic performance.
Our first in the field exploration of ARDS using eGWAS of 120 microarray samples of lung injury identified 14 new molecular targets common to different species and models, suggesting new players in the evolutionarily conserved mechanisms triggered during ARDS.
As the IIS pathway and its major players have been highly conserved throughout evolution, it is conceivable that also the human longevity-enabling FOXO3A variants could function via a similar stress-induced mechanism.
Plk1 belongs to a family of highly conserved serine/threonine kinases, and is a key player in mitosis, where it modulates the spindle checkpoint at metaphase/anaphase transition.
