As the autonomous pathway-map network depends on the γ parameter (the number of conserved pathway maps), we started from the conserved pathway mapsγ and constructed 10,000 patterns of the autonomous pathway mapsγ, at each γ.
The former examined the evolutionary conservation of each pathway map by homology searches, and detected "conserved pathway maps".
It is an evolutionarily conserved pathway and plays important roles in various physiological and pathological conditions such as development, immunity, cancer and neuronal degeneration (Jiang and Mizushima, 2014; Martin et al., 2014).
NOTCH signaling represents an evolutionarily conserved pathway that controls key steps of development, cell growth and differentiation [22].
The IGF signaling pathway is an evolutionarily conserved pathway that plays important roles in regulating growth, development, reproduction, and aging [12], [13].
Nucleotide excision repair (NER) is a highly conserved pathway involved in repair of a wide variety of structurally unrelated DNA lesions [1].
Previous studies demonstrate that the innate immune system, a highly conserved pathway from insects to humans, is vulnerable to signaling disruption by both bacterial and viral pathogens.
Our yeast and mammalian data indicate that ethanolamine treatment triggers autophagy through a phylogenetically conserved pathway.
We defined γ pathway maps in the descending order of OFs as the conserved pathway mapsγ.
IRS1 signaling has been reported to be an evolutionarily conserved pathway regulating mammalian lifespan.
As stated above, autophagy is an evolutionarily conserved pathway to lysosomes (Fig. 1).
