Sentence examples for conserved partner from inspiring English sources
Supporting this observation, yeast two-hybrid analyses confirmed that human and Drosophila nuclear envelope proteins possess conserved partner interactions.
Our identification of an almost invariant motif in the HUS domain argues in favor of this domain interacting with a conserved partner.
Conversely, the RCL of non-inhibitory serpin orthologues is less conserved, with 3 exceptions that presumably bind to conserved partner molecules.
Since it has been proposed that Top3 may be an evolutionarily conserved partner of RecQ helicases, we examined if the expression of WRN could substitute for Sgs1 and hence confer slow growth in the sgs1 top3 background.
Another protein with essential roles in nuclear integrity is BAF, a conserved direct partner for lamins [12], [13] and the LEM-domain family of nuclear proteins.
Based on this observation, we predicted that the human and Drosophila lamins would have conserved interaction partners.
These 3 fly genes (having putative conserved interacting partners in yeast) have 5 potential homologs in human, namely: hRPC155, PAK1B, MAP3K4 (MEKK4), p38MAPKa, and GSPT1.
Interestingly, if we look at the protein binding of the gene pairs we identified, there are some indications these proteins have conserved binding partners.
Note that, although we support our predictions by literature evidences that are mostly based on orthologs, our algorithm actually inferred them from conserved interaction partners as the orthologs in most cases do not carry the annotation we found in the literature.
For each interaction partner, conserved domains (HMMerThread and Pfam) were matched with known domain-domain interactions from iPfam [76].
The greater stability upon concentration of coiled coils formed from all four paralogs over single proteins [13] implies that a proportion of these conserved residues dictate partner selection and protein orientation within the coiled coil, leading to preferential formation of a heterotetrameric structure.
