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HHpred and HHalign combine secondary structure information (conserved over much larger evolutionary distances) with sequence information.
Thus, one explanation for this observation is that functional non-conserved sequences are detectably conserved over shorter evolutionary distances.
The numerical scheme is based on a family of schemes called geometric or discrete variational integrators guaranteeing that the momentum and energy are exactly conserved over long periods of time for conservative systems.
The fact that the unchanging regions are so conserved over the course of evolutionary time means that they perform vital roles and that the virus cannot let them change without perishing.
Caffeine is absorbed through the gastrointestinal tract before being metabolised in the liver and the prevailing theory is that it enhances fat oxidation, allowing muscle glycogen levels to be conserved over a much longer period of time.
All but the V2-binding antibodies were conserved over the 11 years of follow-up.
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To identify sites in 5'UTRs associated with transcript abundance, we performed a search for evolutionarily conserved over-represented sequence elements using the SiteBD program.
The identification of positionally conserved over-represented upstream motifs throws light on putative regulatory elements for transcription in Pf.
Identifying conserved over-represented motifs by ordering genes in this manner may indicate regulatory control for a particular motif.
We applied two pattern finding algorithms MEME [ 9] and AlignACE [ 10] to identify conserved, over-represented DNA motifs.
The study identifies positionally conserved, over-represented motifs in the upstream regions of functionally related, co-expressed Pf genes.
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