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When we searched for the coexpression of enzyme-coding genes directly connected to metabolite pairs whose correlation is conserved, only a small fraction of genes were coexpressed.
In the great apes and Old World monkeys, chromosome-painting reveals that their karyotypes are highly conserved, only a few chromosomal changes differentiate their karyotypes from the ancestral karyotype of all primates [ 46].
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GSMP128940 displays an even more atypical LBD and conserves only a single putative glutamate-interacting residue.
Moreover, 20 unique sequences from the 17 non-conserved miRNA families (i.e., conserved only in a few plant species [ 23]) were detected in TC7d and TD7d libraries.
However, this function appears to be specific to budding yeast: although Srs2 homologues can be identified in other fungi, such as Schizosaccharomyces pombe, a C-terminal SIM is conserved only in a small group of budding yeasts related to Saccharomyces cerevisiae (Fig. 5).
However, because of the species-specific differences in gene regulation due to underlying differences in morphogenesis and development, such as those between different segments of human and rodent prostate [ 81], it can be expected that some functionally important regions will be conserved only in a limited set of genomes where they play a critical role.
Furthermore, the gene-behavior relationships of some behaviors may be conserved only to a certain extent between the human and animal genomes (Chen et al. [2010]).
For example, the N-terminal portion of Cdc16 is conserved only within a small family of yeasts.
An extraordinarily duplicated VirB6 gene encodes five hydrophobic proteins conserved only in a short region known to be involved in DNA transfer in A. tumefaciens.
This motif (AATGAgAATcATTctCATT; lower case indicates less highly conserved) only showed a weak similarity with the E. coli 19 bp Fur-box consensus sequence (GATAATGATAATCATTATC) [44]: it matched this sequence in 10 bp positions out of 19 (52% identity).
Within this group, we could identify phospho-sites conserved only across a narrow number of Bacillus species.
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