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Study design: we compared full length TTV genomic sequences and identified conserved nucleotide patterns in the 5′ and 3′ non-coding regions of the viral genome.
The caliciviruses have conserved nucleotide motifs at the genomic 5´-terminus and at the junction of the coding sequences for the nonstructural/structural proteins.
This mechanism relies on conserved nucleotide motifs, called switch (S) regions, found in DNA upstream of each constant region gene (except in the δ-chain).
Our multiple alignments revealed several conserved nucleotide positions at the 5' end of the COI gene.
All the JH segments had conserved nucleotide sequences at the 3' end.
Phylogenetic analyses were restricted to regions of moderately to highly conserved nucleotide positions that were unambiguously aligned for all sequences.
The best possible match is GTGTGAATCATGAGT, where highly conserved nucleotide positions (frequency at least 90%) are underscored.
Although each type folds into a characteristic structure that is necessary for catalysis, there is almost no widely conserved nucleotide sequence even within each type [1], [2], [3].
Similar(3)
The deduced protein sequence of TC54504 contains two highly conserved nucleotide-binding motifs, similar to other plant homologues [ 9].
To identify ABC transporters from T. castaneum, we performed tblastn searches using the highly conserved nucleotide-binding domains from different insect sources as a query.
To that end, the researchers employed a heterobivalent inhibitor design that exploited the presence of a conserved, nucleotide-binding site on the Fab of IgEs.
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