The highly conserved structural maintenance of chromosomes (Smc) proteins regulate chromosome architecture and organization from bacteria to human.
We, also, identified genome-wide significant associations of two new loci [a conserved telomere maintenance CTC1 and a zinc finger protein 676 ZNF676)] with LTL variation.
This could decrease the rate of C-to-T change in 3rd codon positions, since many of those positions may need to be conserved for maintenance of cis-elements.
These newly identified loci include variants in a conserved telomere maintenance complex component 1 (CTC1; rs3027234, P = 3.6 × 10−8) and in the zinc finger protein 676 (ZNF676; rs412658, P = 3.3 × 10−8) (Fig. 2).
We also identified two novel genomic regions associated with LTL variation that map near a conserved telomere maintenance complex component 1 (CTC1; rs3027234, P = 3.6 × 10−8) on chromosome17p13.1 and zinc finger protein 676 (ZNF676; rs412658, P = 3.3 × 10−8) on 19p12.
The S. cerevisiae nuclear gene ABF2+ encodes a highly conserved mitochondrial DNA maintenance protein, called TFAM in animals, which binds to and bends mitochondrial DNA (mtDNA) [2], [3].
Stochasticity is ubiquitous in natural environments, and risk-sensitivity reflects a phylogenetically conserved adaptation, where maintenance of adequate nutrition and energy stores in the face of this environmental variability is critical for survival and reproduction [4], [5], [6], [7], [8].
The protein encoded by MCM3 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of genome replication.
MCM8 and MCM9, recently discovered members of the highly conserved mini-chromosome maintenance proteins (MCM), are genes implicated in homologous recombination and repair of double-stranded DNA breaks.
MCM4 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication and is highly expressed in esophageal cancer and cervical squamous cell carcinoma [ 21, 22].
