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In the second pattern, demonstrated in three prostate cancer cell lines (DU145, PC-3, 22RV1) and in the immortalized breast normal epithelial cell line, USP19 conserved its ability to positively regulate cell growth through stimulation of progression through G1 into S phase and enhanced the rate of degradation of p27Kip1 (Figs. 1, 2, 4A).
In addition, LOXL2 inactive mutants conserved its ability to cooperate with Snail1 to repress the E-cadherin promoter (Fig. 2B).
Second, KAP1 conserved its ability to repress a chromosomal target in cells where its HCMV silencing activity was abrogated by phosphorylation.
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Mammary gland involution is essential to ensure that the tissue returns to a prepregnancy state and that it conserves its ability to initiate another cycle.
Since protein protein interactions are primarily driven by structural attributes, the ERH interface may be evolutionarily conserved due to its ability to recognize intrinsically disordered regions (IDRs) crucial for the functions of various RNA-binding proteins50.
Our survey focuses on the 18S rRNA gene, commonly used for phylogenetic inference of eukaryotes due to its highly conserved sequence and ability to resolve relatively deep nodes.
The tolerance of FR13A is linked to its ability to conserve respirable reserves by not elongating underwater.
The VOF method is known for its ability to conserve the mass of the traced fluid, also when the fluid interface changes its topology.
To determine whether the ability of poliovirus 3A to inhibit ER-to-Golgi traffic is conserved, the ability of 3A proteins from several picornaviruses, including human rhinovirus 14, foot-and-mouth disease virus, enterovirus 71, hepatitis A, and Theiler's virus, was tested.
Although the tyrosine residues are well conserved, the ability of mammalian tetherins to signal in human cells is highly species specific.
A previous report [ 19] identified the human orthologs of yPOP2 (hPOP2/CandF) and yNOT1 (hNOT1), and showed that they have conserved their ability to bind to each other.
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