An involvement of XPO-1 in miRNA biogenesis is conserved in Drosophila, in which knockdown of Embargoed/XPO-1 or its chemical inhibition through leptomycin B causes pri-miRNA accumulation.
Some introns are highly conserved due to their involvement in certain functions and they may not show enough differences between closely related species [ 24, 25].
Interestingly, despite their rare occurrence, compound microsatellites are most overrepresented in the cds (Table 3) which may indicate that these compound microsatellites are conserved because of an involvement in cellular processes.
The frequency depends on management's mentality but we have to keep in mind that open communication processes and lines conserves employees' commitment and involvement in corporations' targets.
A key function of the PAG that is conserved across mammals is its involvement in the initiation of vocalisation.
Cytidines, being part of highly conserved CpG sequences, have direct involvement in epigenetic gene regulation, developmental processes, and carcinogenesis.
Homologues of the PcG proteins of the FIE-E(Z) complex have been identified in other plant species including monocots, indicating their involvement in a conserved regulatory mechanism among all higher plants [ 17].
The two encoding genes were identified in conserved gene clusters and their involvement in allantoin metabolism (purine degradation via glyoxylate and the glycerate pathway; GK-1, glxK gene, [ 55]) and glucarate and galactarate utilization (GK-2, gclK gene, [ 56]) was demonstrated.
Currently, more and more investigations in functional analysis of conserved miRNAs reveal their involvement in multiple biological and metabolic processes in plants, including induced responses towards abiotic – and biotic stressors, by modulating the expression of their endogenous target genes [ 6- 10].
To probe whether the mechanisms leading to ROS production downstream of oncogenic Ras are conserved in fish, we investigated the involvement of Nox4 in this process.
