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Any two genes that are found together in any pair of genomes are more likely to be conserved in the third genome as well, suggesting that a core of genes tends to be conserved across the entire group.
We identified and confirmed in two cohorts a significant association between NOD2 risk allele count and increased relative abundance of Enterobacteriaceae, with directionality of the effect conserved in the third cohort.
After generating all "dense enriched" subgraphs from each biological network by DENSE, we first detect the β-similar dense subgraphs across two networks based on the Definition 1, and then check if the β-similar dense subgraphs detected in the previous two networks are conserved in the third network.
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Each of the duplicated segments contains calcium-binding residues (asparagines or aspartate) which are highly conserved in the first 12 residues (Fontes and Gilbert 2010).
Several other amino acids are also conserved in the first EF-hands.
The position of the first and last introns is strictly conserved in the first and second LIM domain, respectively.
The analysis grouped the amino acids residues responsible for altered functional constraints into two categories: (I) conserved in the first lineage, but variable in the second lineage; (II) conserved in the second lineage, but variable in the first lineage.
A serine is also highly conserved in the fifth position, as for RNAPII CTD, whereas a basic amino acid (K or R) is invariably conserved in the second position instead of a serine.
Of the three glycines conserved in the second reentrant loop, two create the GXG motif discussed above.
10, 11 Tat shows very little variability and is highly conserved in the first exon among the different subtypes, with the exception of the O subtype.
In particular, while the length of introns was perfectly conserved in the first part of the gene (introns 1 and 2), introns 3 to 6 were all shorter in the HM126469 sequence than in HM126467.
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CEO of Professional Science Editing for Scientists @ prosciediting.com