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For this purpose, we first estimated the cut-off value of the motif conservation score (MCS) to identify conserved functional STAT3 TFBSs.
This in turn makes it less accurate in detecting conserved functional modules or predicting protein function.
Like other conserved functional genes, LSGs play important roles in biological evolution and functions.
These broadly neutralizing antibodies generally target conserved functional regions on the major influenza surface glycoprotein hemagglutinin (HA).
The engineering of RNA compounds is an effective strategy for targeting conserved functional regions in viral RNA genomes.
Although homologous RNAs from different organisms can be structurally diverse, they adopt a structurally conserved functional core that includes preassembled active and/or substrate binding sites.
Despite their small molecular size and their conserved functional domain of two distinct EF-hands, S100 proteins developed a plethora of tissue-specific intra- and extracellular functions.
As we shown in this study, CCCH motif is a highly conserved functional unit.
Osteopontin contains highly conserved functional domains, including calcium and heparin binding regions and a cell adhesion motif.
While expression patterns alone do little to inform the precise functions of genes, similar expression of orthologous genes across related phyla often reflects conserved functional relationships.
Natural substitutions across the conserved functional domains were observed.
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