Generally, there are three rough criteria rules to be considered when choosing an essential cellular function as an antibacterial drug target [ 7]: Rule 1) the highly conserved function in a range of pathogens and the conserved level (sequence or function) in different pathogens; Rule 2) essentiality of the gene for the bacteria; and Rule 3) having no highly conserved function in humans.
The two other genes have homologs in a wide range of taxa, with which they share short conserved sequence regions; one of these genes may have a highly conserved function in controlling sperm flagellum motility.
The Drosophila gut and fat body, the latter functionally equivalent to mammalian liver and adipose, have an evolutionarily conserved function in aging (Fontana et al., 2010).
Despite this, there is a family of DM-domain transcription factors (Dmrts), which hold a highly conserved function in sexual development.
Further, mdf-1 (mitotic arrest defective) and mdf-2 were identified as homologs of MAD1 and MAD2, and both exhibited conserved function in nematode and yeast [3].
YAP has an evolutionarily conserved function in organ size control.
Hence, genes with a presumably conserved function in sex determination in cichlids are clustering on the sex-linked LGs (the potential sex chromosomes) in the Nile tilapia.
Thus, we can predict with great certainty that the snR30/U17 snoRNA has an evolutionarily conserved function in pre-rRNA processing.
This gene encodes a homolog of YhbH, which is a short hibernation promoting factor (HPF) with a highly conserved function in γ-Proteobacteria [ 60].
Next, applying an e-value cutoff of e−4 resulted in 15,983 (88%) likely unigenes with a putatively conserved function in Arabidopsis.
Brachyury is a T-box transcription factor with an evolutionarily conserved function in vertebrate development, whereby it is required for mesoderm formation [ 13- 15].
