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Exact(7)
Interestingly, we have also found that mutating the highly conserved equivalent residues in WNK1 ablates interaction with KLHL3.
Our understanding of poly(A) site evolution is limited by the lack of a reliable identification of conserved, equivalent poly(A) sites among species.
A comparison with the highly conserved equivalent gene sequence from Aspergillus oryzae shows that the internal region between these two ESTs contains no other introns.
To investigate the pathogenicity of vps35 mutations in vivo, we generated transgenic Drosophila that express variant forms of human VPS35 or, where these residues are conserved, equivalent variants of Drosophila vps35.
As a result, the carboxylic counterion is no longer electrostatically coupled to the conserved equivalent of Arg82, in contrast to BR.
Moreover, the most conserved equivalent exons belong to clusters of consecutive equivalent exons, indicative of a high conservation of gene structure, and are located in the central and C-terminal protein regions.
Similar(52)
We note that organisms with similar lifestyles across a wide phylogenetic range tend to conserve equivalent interactions and network motifs.
It is known from both a large-scale protein-protein interaction study [ 30] and specific studies [ 2, 31, 32] that the ancestor protein to Akirin1 and Akirin2 has many binding partners (>20 are currently known) and several of these are conserved in equivalent vertebrate pathways (see section: 'a synthesis of information on akirin function').
While the total mass of each terrain type is conserved by the equivalent rock height approach, the geometry of the masses is changed, most prominently over the oceans (shallower with a density of 1030 kg/m3 for ocean water) and ice-covered areas (lower elevation with a density of 927 kg/m3 for ice), while the global topography remains unchanged.
These data suggested that A. oryzae has no highly conserved sequence element equivalent to AAUAAA, a mammalian polyadenylation signal.
Although an acidic residue is highly conserved at the equivalent position to Glu300 on H7, the preceding residue is often either phenylalanine or tyrosine (Supplementary Figure S1), suggesting that Glu299 is playing a structural or stabilizing role unique to PepTSt.
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