Sentence examples for conserved effect from inspiring English sources

Due to the apparent evolutionarily conserved effect of Sir2/S irt1 on health and ageing, the physiological functions and protein targets of the enzyme have been intensively studied in mammals in order to cure age-related diseases.

To evaluate whether genistein exerted a conserved effect on human hepatocytes, we tested the compounds in human hepatoma (HepG2) cells.

The action of naringenin on cell growth in the phylogenetically diverse systems of Dictyostelium and mammalian kidney cells, suggests a conserved effect mediated by TRPP2 (polycystin-2).

Despite of the differences on the level of individual genes we observed a conserved effect of TGF-β1 stimulation on a number of biological processes and pathways.

In the presence of Hh, the ensuing Hh signaling blocks the cleavage of Gli3 into Gli3R and stabilizes Gli2 that can then be N-terminally truncated into its activator form (Gli2A). Overall, the conserved effect of Hh is to switch the Glis from repressors into activators and allow for well-coordinated transcriptional events.

A similar expression pattern was observed in MIN6 cells exposed to a proinflammatory cytokines mix; this effect was observed also in mouse islets and in human islets, thus highlighting a conserved effect on the expression of miR-29 family members following beta-cell exposure to cytokines [ 43].

Early comparative bioinformatics analysis has suggested a limited role for AS in plants in terms of functional expansion of the proteome35,36,37; only a small number of AS events have conserved effects at the protein sequence level in Arabidopsis and rice37.

Although a considerable number of functional AS events in plants have been described in literature [ 5], we have shown here that only a small number of AS events have conserved effects at the protein sequence level in Arabidopsis and rice.

It has been noted previously that recruited LTRs often have a taxon-specific regulation even if they are present in multiple species (Cohen et al. 2009; Ward et al. 2013; but see Sundaram et al. 2014 for conserved effects also).

In a longitudinally designed study, we tested whether an isoflavone enriched soy extract (SE) stimulated peak bone gain in rats during growth and maturity so as to confer better bone conserving effect after ovariectomy with concurrent treatment discontinuation.

Crop genotypes with root traits permitting increased nutrient acquisition would increase yields in low fertility soils but have uncertain effects on soil fertility in the long term because of competing effects on nutrient removal vs. the soil conserving effects of greater crop biomass.