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Thank you for sending your work entitled "Multi-species, multi-transcription factor binding highlights conserved control of tissue-specific biological pathways" for consideration at eLife.
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We also observed differences in expression profiles in the brains of dominant versus subordinate females that suggested sex-conserved control of aggression.
We analyzed mtDNA polymorphisms (a total of 741 bp from a part of conserved control region, ND5, ND2, Cyt b and 12S) in 91 scats and 12 tissue samples of Bengal tiger (Panthera tigris tigris) populations across Terai Arc Landscape (TAL) located at the foothills of Himalayas in North Western India, Buxa Tiger Reserve BTRR), and North East India.
Thus, the fraction of conserved control elements among the uORFs contained within the alternative regions of mammalian 5'UTRs is lower than that in constitutive regions.
Considering the growing evidence for the importance of aggregation in various physiological processes, the conserved differential control of aggregation-prone proteins may be part of a general regulatory framework that not only minimizes unwanted/potentially harmful aggregation, but also keeps functional aggregation in check (see below).
Herein, we describe the isolation of a GS line in such a screen that allowed us the identification and characterization of a conserved mechanism of control of ligand-mediated Notch activation by the miR-8 (known as miR-200) family of microRNAs (miRNAs).
The Drosophila retinoblastoma family members RBf1 and RBf2 are structurally similar to the vertebrate proteins and possess functionally conserved activities in control of cell cycle and developmental genes (reviewed in Du and Pogoriler 2006).
Centrosome duplication is initiated at the G1/S transition by the sequential recruitment of a set of conserved proteins under the control of the kinase Plk4.
We hypothesize that comparing patterns of genetic control of conserved developmental processes among animal species may be fruitful for other, not only neurological, developmental processes.
The centrosome duplication is initiated at the G1/S transition by the sequential recruitment of a set of conserved proteins under the control of Plk-4 and the related kinase Zyg-1 in C.elegans [2] [5].
These results suggested that transcriptional regulation of this multigenic family is under control of conserved regulatory elements in microsporidia.
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