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Thank you for sending your work entitled "Multi-species, multi-transcription factor binding highlights conserved control of tissue-specific biological pathways" for consideration at eLife.
We analyzed mtDNA polymorphisms (a total of 741 bp from a part of conserved control region, ND5, ND2, Cyt b and 12S) in 91 scats and 12 tissue samples of Bengal tiger (Panthera tigris tigris) populations across Terai Arc Landscape (TAL) located at the foothills of Himalayas in North Western India, Buxa Tiger Reserve BTRR), and North East India.
Alternatively it could represent a conserved control element for these highly expressed proteins.
Thus, the fraction of conserved control elements among the uORFs contained within the alternative regions of mammalian 5'UTRs is lower than that in constitutive regions.
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Results show the proposed approach conserves control effort compared to tracking the desired equilibrium directly.
During evolution, multiple mechanisms have been conserved to control body weight in animals.
Two highly conserved internal control regions, the A and B boxes, together form a specific binding site for the multisubunit transcription factor IIIC (TFIIIC).
tDNAs in the fission yeast genome range in size from 71 102 bp and are characterized by highly conserved internal control elements.
These results have raised the question of how broadly conserved the control of transcription is across apicomplexans.
Taken together, these observations indicate that ALT regions are subject to a weaker purifying selection than CONSTIT regions, however, a fraction of the uORFs in the ALT regions could represent conserved translational control elements.
The PLCβ regulator, STOPS, is critical for maintaining protein, but not mRNA, levels of NORPA [ 124] suggesting conserved rhythmic control of visual signal transduction could be tightly regulated by NORPA through rhythmic expression of norpA as well as through STOPS.
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