Sentence examples for conserved context from inspiring English sources

A popular method to roughly determine whether a DNA sequence is functional is to evaluate its conserved context [ 45- 47].

Such an example can be found in one of the strongest T1D associations, which involves the R620W SNP in PTPN22 (protein tyrosine phosphatase, non-receptor type 22), where the 620W disease-associated variant, derived in an even more conserved context, is a gain-of-function variant, with increased catalytic activity [36].

Interestingly, in S. aurantiaca, a gene coding for the enzyme responsible for the last step of the pathway leading from IPP to squalene (squalene synthase) is found in between ERG1 and ERG7 (fig. 5), leading to a conserved context for three enzymes acting consecutively.

To do this, we split the expression context conservation scores of all 1 2 orthologous groups into two data sets: one containing the highest (most conserved) expression context conservation scores, the other containing the lower (less conserved) scores.

For a genome wide analysis of miRNA targets, we employed the TargetScan Mouse data sets of 'Conserved site context + score' and 'Nonconserved site context + score' (Methods).

A few taxa did not present any particularly conserved genomic context nor did they harbor the conserved genes found in Group 1 or Group2 synteny patterns.

"Nuclear structure" (Y) for example has a large fraction of genes with a highly conserved expression context, while "Cell wall/membrane/envelope biogenesis" (M) and "Extracellular structures" (W) have a low expression context conservation.

Conserved genomic context may therefore be useful in lieu of primary sequence homology in annotating putative candidate loci for their potential biological functions.

Finally, our model should be tested with other α-proteobacteria possessing homologues of the PTS regulatory proteins and the crucial two component system encoded by genes arranged in a strictly conserved genomic context.

Members of the SpsA subfamily do not have a conserved chromosomal context.

Conserved gene context is used in many types of comparative genome analyses.