Sentence examples for conserved contact from inspiring English sources

Of note, several TCR Vβ residues make contacts to HLA-DR4 Gln57α, Ala61α and Gln70β, which stand out as MHC class II conserved contact residues from the analysis of TCR/p/MHC crystallographic complexes [29].

One, very significant and highly conserved contact was observed on all 11 pMHC-II interfaces.

We counted how many amino acid types observed in all or in conserved contact positions of CCT monomers were also observed in the T. acidophilum Thsa sequence, in human CCT8Ls or in human BBS sequences (Table 5).

Most contacts between TCR and peptide occur through the CDR3 loops, which exhibit the greatest degree of variability whereas the preponderance of generally conserved contacts with the MHC α helices is mediated through CDR1 and CDR2 [14].

Remarkably, two "hotspots" on TCR VB1OE (Leu32 in CDR1 and Tyr52 in CDR2, see Table 6) interact with DR4α Gln57 and Ala61 (Table 4) which form conserved contacts with TCR Vβ domain [29].

The list of contacts obtained for the model is compared to the list of 24 conserved contacts.

The basic assumption in our GLAS scoring function is that high-quality GPCR models must show a large number of these 24 conserved contacts.

Maintenance of this elaborate architecture depends on the evolutionarily conserved mitochondrial contact site and cristae organizing system (MICOS), a multisubunit inner membrane protein complex.

The evolutionarily conserved mitochondrial contact site and cristae organizing system (MICOS) connects the two inner membrane domains via formation and stabilization of crista junction structures.

Specific comments: 1) The analysis of the effect of mutations within Scc2 that alter conserved Scc4 contact residues (Results) is not state of the art and raises important issues.

The highly conserved Ile-1174 contactseveralal other residues in α6 of the DH domain, including Lys-1420, Ser-1423, Asp-1424, and Leu-1426.