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Recently, microRNAs (miRNAs), an evolutionarily conserved class of small non-coding RNAs (of 18 24 nucleotides), have emerged as pivotal regulators of gene expression and are involved in a variety of cellular processes, including differentiation, growth control, and cell fate determination (reviewed in ).
Social insect queens use an ancient, evolutionarily conserved class of pheromones to prevent worker reproduction.
The 60kDa heat shock protein family, HSP60, constitutes an abundant and highly conserved class of molecules.
MiRNAs are an evolutionarily conserved class of endogenous small non-coding RNAs.
The 60kDa heat shock protein family, Hsp60, constitutes an abundant and highly conserved class of molecules that are highly expressed in chronic-inflammatory and autoimmune processes.
MicroRNAs (miRNAs) are a highly conserved class of noncoding RNA that control many biological processes by sequence-specific inhibition of gene expression.
The LDL receptor gene family is a highly conserved class of cell surface receptors involved in various functions, including cell signaling, cargo transport, and gene regulation [1].
The SVM when trained on targets could predict the "ancient" (deeply conserved) class of validated Arabidopsis MIRNA genes with an accuracy of 84%, and 76% for "new" rapidly-evolving MIRNA genes.
To further analyse the co-clustering trend of annotated bPOPs, we identified conserved class specific sequence motifs.
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Interestingly, class-B GPCRs also contain conserved (class-specific) polar residues in their TM cores (Wootten et al., 2013; Hollenstein et al., 2013; Siu et al., 2013), including proton-titratable residues (e.g. the H2.50b-E3.50b pasr (as per Wootten numbering (Wootten et al., 2013))).
A group of highly conserved, class-specific LIC3 residues surround this universally conserved, hydrophobic patch.
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